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Lamisil 31. Khanna, D.; McMahon, M.; and Furst, D. E.: Safety of tumour necrosis factor-alpha antagonists. Drug Saf, 27 5 ; : 307-24, 2004, [S]. 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HeiankyoView, a novel hierarchical data visualization technique is introduced to visualize large-scale multidimensional chemical information. HeiankyoView is applied to visualize aqueous solubility data for 908 compounds collected from the literature. The results of a recursive partitioning analysis and hierarchical clustering analysis are visualized, the trends hidden in the solubility data is effectively displayed as intuitively understandable visual images. This is a powerful tool to help us to understand structure-activity relationship from a largescale data set. This study is emphasizing to achieve improved specificity and sensitivity of pharmacophore-based virtual screening. Human immunodeficiency virus protease and its inhibitors PIs ; are used, including the selection of chemical features, involvement of excluded volumes EV ; , the tolerance radius of excluded volumes, energy windows, and the maximum number of conformers in conformation generation. Protein flexibility is simulated by adjusting the sizes of EV. The best pharmacophore model, combining both chemical features and excluded volumes, is able to correctly identify 60 out of 75 structurally diverse known PIs, while misclassifying only 5 out of 75 similar compounds that are not inhibitors. Study Results When compared to placebo treatment, a one week twice daily application of LAMISIL 1% solution spray was significantly more effective in the treatment of Pityriasis versicolor. Treatment was effective in 70% of LAMISIL treated patients compared to 32% patients who used placebo p 0.001 ; . At the end of the study there was also a significant difference between the numbers of patients with negative microscopy, who had received LAMISIL * treatment 79% ; compared to the placebo treated 44% ; [p 0.001]. 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